{"product_id":"douvistome-oxiclozanid-34mg-oral-suspension-for-cattle-and-sheep","title":"DOUVISTOME  Oxiclozanid 34mg oral suspension for cattle and sheep","description":"PRODUCT NAME\u003cbr data-mce-fragment=\"1\"\u003eDUOVISTOME 34 mg\/ml\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eOral suspension for bovine animals and sheep\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eDECLARATION (SUBSTANCE) OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS (INGREDIENTS)\u003cbr data-mce-fragment=\"1\"\u003eComposition for 1 ml:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eActive substance:\u003cbr data-mce-fragment=\"1\"\u003eOxyclazandid 34 mg.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eFARMACEUTIC FORM:\u003cbr data-mce-fragment=\"1\"\u003eOral suspension. Cream-coloured suspension, homogeneous after shaking.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eCLINICAL PARTICULARITIES\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eTarget species\u003cbr data-mce-fragment=\"1\"\u003eCattle and sheep.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIndications for use, specifying target species\u003cbr data-mce-fragment=\"1\"\u003eIn bovine and ovine animals:\u003cbr data-mce-fragment=\"1\"\u003e- Treatment and control of Fasciolosis (Fasciola hepatica, Fasciola gigantica) Paraphystomosis (Paraphistomum spp.)\u003cbr data-mce-fragment=\"1\"\u003e- Removal of cestode segments.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eContraindications\u003cbr data-mce-fragment=\"1\"\u003eDo not use in animals with known hypersensitivity to the active substance or any of the excipients.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSpecial warnings for target species\u003cbr data-mce-fragment=\"1\"\u003eCertain precautions should be taken to avoid the following practices, as they may increase the risk of developing resistance and thus to inefficiency of treatment:\u003cbr data-mce-fragment=\"1\"\u003e- too frequent and repeated use of antiheimiths of the same class for an extended period of time;\u003cbr data-mce-fragment=\"1\"\u003e- underdosing, which may be due to an underestimation of body mass, misadministration of the product or non-calibration of the dosing device (if any).\u003cbr data-mce-fragment=\"1\"\u003eAll suspected cases of antihelmintic resistance should be further investigated using appropriate tests (e.g. fecal egg count test). Where tests clearly suggest resistance to a particular antihelmintic, another of another pharmacological class whose mode of action is different shall be used.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSpecial precautions for use\u003cbr data-mce-fragment=\"1\"\u003eSpecial precautions for use in animals\u003cbr data-mce-fragment=\"1\"\u003eBefore calculating the dose, the weight of the animals should be assessed as accurately as possible.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eAdverse reactions (frequency and severity)\u003cbr data-mce-fragment=\"1\"\u003eThe side effects generally observed are: anorexia, diarrhea or prostration.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eUse during gestation, lactation or laying period\u003cbr data-mce-fragment=\"1\"\u003eDuring the studies carried out in target species at different reproductive stages, no fetotoxic, teratogenic or negative effects on fertility were observed.\u003cbr data-mce-fragment=\"1\"\u003eThe product can be administered during the gestation period.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eInteractions with other medicinal products or other forms of interaction\u003cbr data-mce-fragment=\"1\"\u003eThey don't know each other.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eQuantities to be administered and route of administration:\u003cbr data-mce-fragment=\"1\"\u003eCattle: 10 mg oxyclozanid \/ kg body weight, which corresponds to 3 ml Douvistome \/ 10 kg body weight, administered orally. The maximum dose of 3,5 g oxyclozanid per animal, i.e. 100 ml Douvistome\/animal, should not be exceeded.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSheep: 15 mg oxyclozanid \/ kg body weight, which corresponds to 4.5 ml Douvistome \/ 10 kg body weight, administered orally. The maximum dose of 0,68 g oxyclosandid per animal, i.e. 20 ml Douvistome\/animal, should not be exceeded.\u003cbr data-mce-fragment=\"1\"\u003eIn order to ensure the correct dose, it is recommended to correctly estimate body weight to avoid overdose or underdosing, the accuracy of the measuring device should also be checked.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eOverdose (symptoms, emergency procedures, antidotes), as appropriate\u003cbr data-mce-fragment=\"1\"\u003eIf the dose of 15 mg\/kg is exceeded, anorexia, diarrhoea, prostration may be observed.\u003cbr data-mce-fragment=\"1\"\u003eCases of mortality may occur if the dose exceeds 50 mg\/kg.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eWaiting time:\u003cbr data-mce-fragment=\"1\"\u003eCattle:\u003cbr data-mce-fragment=\"1\"\u003eCams and organs: 13 days.\u003cbr data-mce-fragment=\"1\"\u003eMilk: 108 hours (4.5 days)\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSheep:\u003cbr data-mce-fragment=\"1\"\u003eMeat and organs: 14 days.\u003cbr data-mce-fragment=\"1\"\u003eMilk: 7 days.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eFARMACOLOGICAL PROPERTY\u003cbr data-mce-fragment=\"1\"\u003ePharmacotherapeutic group: antihelmintics, phenol derivatives including salicylanilide, oxyclozanide.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003ePharmacodynamic properties\u003cbr data-mce-fragment=\"1\"\u003eOxyclozanide was used for its fasciolicactionde action in 1966. It is a white non-hygroscopic crystalline powder and virtually insoluble in water. Animals are usually treated with an aqueous solution containing 34 mg oxyclozanid \/ ml.\u003cbr data-mce-fragment=\"1\"\u003eThe main indications of oxyclozanide are: treatment and control of faciolose, paraphystomosis and cestoses (removal of proglots) in cattle and sheep. The primary action of salicylates has generally been associated with the release of oxidative phosphorylation. Salicylanids are 1000 to 10 000 times more active than dinitrophenol, a previous compound known as an inhibitor of oxidative phosphorylation.\u003cbr data-mce-fragment=\"1\"\u003ePharmacodynamic properties\u003cbr data-mce-fragment=\"1\"\u003eOxyclozanide was used for its fasciolicactionde action in 1966. It is a white non-hygroscopic crystalline powder and virtually insoluble in water. Animals are usually treated with an aqueous solution containing 34 mg oxyclozanid \/ ml.\u003cbr data-mce-fragment=\"1\"\u003eThe main indications of oxyclozanide are: treatment and control of faciolose, paraphystomosis and cestoses (removal of proglots) in cattle and sheep. The primary action of salicylates has generally been associated with the release of oxidative phosphorylation. Salicylanids are 1000 to 10 000 times more active than dinitrophenol, a previous compound known as an inhibitor of oxidative phosphorylation.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003ePharmacokinetic peculiarities:\u003cbr data-mce-fragment=\"1\"\u003eAfter oral administration to ruminants, the maximum plasma concentration (Cmax) is reached 24 hours later indicating a very rapid absorption process. The rate of gastrointestinal absorption is slow in sheep, most likely due to slower transit. The limit and rate of absorption of oxyclozanide are dose dependent. A linear increase in the plasma concentration of oxyclozanide is observed in cattle at doses between 10 and 15 mg\/kg body weight.\u003cbr data-mce-fragment=\"1\"\u003eOxyclozanide and halogenated salicylates are extensively palsmatically bound and little distributed in tissues. This extensive plasma binding is responsible for the long half-life of elimination. Oxyclozanid is very little metabolized and is eliminated mainly unmodified.\u003cbr data-mce-fragment=\"1\"\u003eA glucuronide metabolite of oxyclozanide has been identified. This active antihelmintic glucuronid is excreted by bile in high concentrations near adult fascioles. This bile excretion is an important pathway for active fasciolicids against adult parasites in the bile ducts.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eFARMACEUTIC PARTICULARITIES\u003cbr data-mce-fragment=\"1\"\u003eList of excipients:\u003cbr data-mce-fragment=\"1\"\u003eMethylparahydroxybenzoate, propylparahydroxybenzoate, sodium melibisulphite, magnesium and aluminium silicate, sodium carmelose, sodium lauri sulphate, sodium citrate, purified water.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIncompatibilities\u003cbr data-mce-fragment=\"1\"\u003eThey don't know each other.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eShelf life:\u003cbr data-mce-fragment=\"1\"\u003eShelf life as packaged for sale: 3 years.\u003cbr data-mce-fragment=\"1\"\u003eShelf life after the first opening of the primary packaging: 3 months.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSpecial storage precautions:\u003cbr data-mce-fragment=\"1\"\u003eIt does not require special storage conditions.\u003cbr data-mce-fragment=\"1\"\u003e","brand":"WWW.PROFISUPPLIER.COM","offers":[{"title":"1L","offer_id":57515794465099,"sku":null,"price":44.9,"currency_code":"EUR","in_stock":true},{"title":"5L","offer_id":57515794497867,"sku":null,"price":199.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0548\/9662\/3865\/files\/douvistome_317669fb-ddb9-42b8-9535-645ed71f80af.png?v=1780660056","url":"https:\/\/profisupplier.com\/en-pk\/products\/douvistome-oxiclozanid-34mg-oral-suspension-for-cattle-and-sheep","provider":"WWW.PROFISUPPLIER.COM","version":"1.0","type":"link"}